API

URL

https://synvar.sibils.org/generate/literature/fromMutation

Parameters

• ref: Gene name or chromosome number or name (e.g. JAK2, BRAF, 9, X). Optional if an identifier is given in the variant parameter.

• variant: Variant description, COSMIC id, or dbSNP id (e.g. V617F, Val600Glu, rs113488022, COSM476).

• level: Level of the provided variant description (protein, transcript, genome, dbsnp or cosmic).

Optional parameters

• iso: Validate on and generate synonyms for isoforms: false (default) or true.
• map: Output syntactic variations even if the variant could not be mapped on genome: false (default) or true.
• format: Output format: xml (default) or beacon (json).

Examples

• https://synvar.sibils.org/generate/literature/fromMutation?ref=BRAF&variant=V600E&level=protein

• https://synvar.sibils.org/generate/literature/fromMutation?ref=BRAF&variant=V600E&level=protein&format=beacon&iso=true

• https://synvar.sibils.org/generate/literature/fromMutation?variant=5279C%3EA&ref=BRCA2&level=transcript

• https://synvar.sibils.org/generate/literature/fromMutation?ref=&variant=rs113488022&level=dbsnp

• https://synvar.sibils.org/generate/literature/fromMutation?ref=&variant=COSM476&level=cosmic

• https://synvar.sibils.org/generate/literature/fromMutation?ref=BRAF&variant=V600K&level=protein&map=false